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Figure 2: Progress of the synthesis strategy for conolidine impressed with the biosynthetic proposal to the conversion of stemmadenine to vallesamine.

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Getting the pharmacodynamics of conolidine and cannabidiol employing a cultured neuronal network dependent workflow

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To this conclude, cultured neuronal networks grown on MEAs coupled with sample recognition procedures to make a database of drug-reaction purposeful profiles has aided the classification and identification of the MOA of novel chemical entities6,seven.

Cultures comprised of excitatory neurons, inhibitory neurons and glia self-assemble into spontaneously firing two-dimensional networks that share numerous practical and structural characteristics with in vivo